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KMID : 0376219810180020265
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Chonnam Medical Journal
1981 Volume.18 No. 2 p.265 ~ p.269
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Effects of Several Autonomic Drugs on the Parotid Salivation and the Duct Pressure in Cats
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Abstract
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In urethane-anesthetized cats, effects of several autonomic drugs on the parotid salivation and the intraluminal pressure of the parotid duct were observed. The results obtained were as follows.
1. There was no spontaneous secretion from the parotid gland.
2. Intravenous pilocarpine evoked copious salivation, but norepinephrine did not elicit any salivation.
3. Parotid salivation caused by constant intravenous infusion of pilocarpine was reduced either by norepinephrine or by superimposed excitation of the cervical sympathetics. These effects of norepinephrine and the cervical sympathetics were abolished in the presence of phenoxybenzamine.
4. Parotid salivation caused by pilocarpine was immediately ceased by atropine.
5. Intravenous pilocarpine elicited an increase of the duct pressure which remained on a plateau for a while, whereas norepinephrine caused no changes in the duct pressure.
These results suggest that the cholinergic fibers to the parotid gland play a role in producing salivation, but the adrenergic fibers play a role in inhibiting salivation.
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